1,512 research outputs found
Putting theory into practice - a case study in one U.K. Medical school of the nature and extent of unprofessional behaviour over a 6-year period
Producing a medical profession which is fit for the demands and expectations of society involves ensuring that practitioners learn what it means to behave in a 'professional' way. Codes of professional conduct have been developed for medical students in the UK, but the literature on how medical schools actually apply these is small. More detail is needed to evaluate approaches to assessing professionalism, or to analyse the extent to which students 'fail' this aspect
A Foucauldian Interpretation of Paralympic Sport in the United Arab Emirates: An Exploration Through a Virtual Lens
© 2018 Informa UK Limited, trading as Taylor & Francis Group. In this paper, we explore the interface between the construction of disability and the culture of the United Arab Emirates (UAE) with a focus on the implications that these have on the provision for Paralympic sport. Despite the previous literature that has investigated the relationship between sport and the Arab world, there is a significant void at the intersection between disability and sport within the Arab community. This paper uses a Foucauldian lens to unpack the relationship between the concepts of disability and Arab culture and how these are linked to Paralympic ethos. To achieve this aim, this paper uses virtual ethnographic methods. The internet is a flexible tool often understood as a cultural artefact which is socially constructed and a technology that was produced by particular people which contextually situated priorities. It is also a technology which is shaped by the ways in which it is marketed, taught and used. We believe the internet integrates with traditional cultures therefore providing a greater understanding and continual observation of Paralympic sport in the UAE
Perinatal Gene Transfer to the Liver
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect.
Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first
weeks or months of life is inevitable. Some diseases can be managed using conventional medicines whereas others are, as yet, untreatable.
In this review we consider the application of early intervention gene therapy in neonatal and fetal preclinical studies. We appraise
the tools of this technology, including lentivirus, adenovirus and adeno-associated virus (AAV)-based vectors. We highlight the application
of these for a range of diseases including hemophilia, urea cycle disorders such as ornithine transcarbamylase deficiency, organic
acidemias, lysosomal storage diseases including mucopolysaccharidoses, glycogen storage diseases and bile metabolism. We conclude by
assessing the advantages and disadvantages associated with fetal and neonatal liver gene transfer
D=3, N=8 conformal supergravity and the Dragon window
We give a superspace description of D=3, N=8 supergravity. The formulation is
off-shell in the sense that the equations of motion are not implied by the
superspace constraints (but an action principle is not given). The multiplet
structure is unconventional, which we connect to the existence of a "Dragon
window", that is modules occurring in the supercurvature but not in the
supertorsion. According to Dragon's theorem this cannot happen above three
dimensions. We clarify the relevance of this window for going on the conformal
shell, and discuss some aspects of coupling to conformal matter.Comment: plain tex, 24 pp v2: minor change
On duality symmetries of supergravity invariants
The role of duality symmetries in the construction of counterterms for
maximal supergravity theories is discussed in a field-theoretic context from
different points of view. These are: dimensional reduction, the question of
whether appropriate superspace measures exist and information about non-linear
invariants that can be gleaned from linearised ones. The former allows us to
prove that F-term counterterms cannot be E7(7)-invariant in D=4, N=8
supergravity or E6(6)-invariant in D=5 maximal supergravity. This is confirmed
by the two other methods which can also be applied to D=4 theories with fewer
supersymmetries and allow us to prove that N=6 supergravity is finite at three
and four loops and that N=5 supergravity is three-loop finite.Comment: Clarification of arguments and their consistency with higher
dimensional divergences added, e.g. we prove the 5D 4L non-renormalisation
theorem. The 4L N=6 divergence is also ruled out. References adde
N=2 Conformal Superspace in Four Dimensions
We develop the geometry of four dimensional N=2 superspace where the entire
conformal algebra of SU(2,2|2) is realized linearly in the structure group
rather than just the SL(2,C) x U(2)_R subgroup of Lorentz and R-symmetries,
extending to N=2 our prior result for N=1 superspace. This formulation
explicitly lifts to superspace the existing methods of the N=2 superconformal
tensor calculus; at the same time the geometry, when degauged to SL(2,C) x
U(2)_R, reproduces the existing formulation of N=2 conformal supergravity
constructed by Howe.Comment: 43 pages; v2 references added, acknowledgments update
Transcript Level Responses of Plasmodium falciparum to Antimycin A
The mitochondrial electron transport chain is essential to Plasmodium and is the target of the antimalarial drug atovaquone. The mitochondrial genomes of Plasmodium sp. are the most reduced known, and the majority of mitochondrial proteins are encoded in the nucleus and imported into the mitochondrion post-translationally. Many organisms have signalling pathways between the mitochondria and the nucleus to regulate the expression of nuclear-encoded mitochondrially-targeted proteins, for example in response to mitochondrial dysfunction. We have studied the transcript profiles of synchronous Plasmodium falciparum treated with an LD50 concentration of the complex III inhibitor antimycin A, to investigate whether such pathways exist in the parasite. There was a broad perturbation of gene expression. The differentially expressed genes were enriched for transcripts encoding proteins involved in invasion, stress response, nucleotide biosynthesis and respiration. Some effects were attributable to a delay in the gene expression phase of drug-treated parasites. However, our data indicated regulation of mitochondrial stress response genes and genes involved in pyrimidine biosynthesis, implying the existence of a signalling pathway from the mitochondrion to the nucleus
A Self-Reference False Memory Effect in the DRM Paradigm: Evidence from Eastern and Western Samples
It is well established that processing information in relation to oneself (i.e., selfreferencing) leads to better memory for that information than processing that same information in relation to others (i.e., other-referencing). However, it is unknown whether self-referencing also leads to more false memories than other-referencing. In the current two experiments with European and East Asian samples, we presented participants the Deese-Roediger/McDermott (DRM) lists together with their own name or other people’s name (i.e., “Trump” in Experiment 1 and “Li Ming” in Experiment 2). We found consistent results across the two experiments; that is, in the self-reference condition, participants had higher true and false memory rates compared to those in the other-reference condition. Moreover, we found that selfreferencing did not exhibit superior mnemonic advantage in terms of net accuracy compared to other-referencing and neutral conditions. These findings are discussed in terms of theoretical frameworks such as spreading activation theories and the fuzzytrace theory. We propose that our results reflect the adaptive nature of memory in the sense that cognitive processes that increase mnemonic efficiency may also increase susceptibility to associative false memories
N=2 supergravity and supercurrents
We address the problem of classifying all N=2 supercurrent multiplets in four
space-time dimensions. For this purpose we consider the minimal formulation of
N=2 Poincare supergravity with a tensor compensator, and derive its linearized
action in terms of three N=2 off-shell multiplets: an unconstrained scalar
superfield, a vector multiplet, and a tensor multiplet. Such an action was
ruled out to exist in the past. Using the action constructed, one can derive
other models for linearized N=2 supergravity by applying N=2 superfield duality
transformations. The action depends parametrically on a constant non-vanishing
real isotriplet g^{ij}=g^{ji} which originates as an expectation value of the
tensor compensator. Upon reduction to N=1 superfields, we show that the model
describes two dually equivalent formulations for the massless multiplet
(1,3/2)+(3/2,2) depending on a choice of g^{ij}. In the case g^{11}=g^{22}=0,
the action describes (i) new minimal N=1 supergravity; and (ii) the
Fradkin-Vasiliev-de Wit-van Holten gravitino multiplet. In the case g^{12}=0,
on the other hand, the action describes (i) old minimal N=1 supergravity; and
(ii) the Ogievetsky-Sokatchev gravitino multiplet.Comment: 40 pages; v2: added references, some comments, new appendi
Variant supercurrent multiplets
In N = 1 rigid supersymmetric theories, there exist three standard
realizations of the supercurrent multiplet corresponding to the (i) old
minimal, (ii) new minimal and (iii) non-minimal off-shell formulations for N =
1 supergravity. Recently, Komargodski and Seiberg in arXiv:1002.2228 put
forward a new supercurrent and proved its consistency, although in the past it
was believed not to exist. In this paper, three new variant supercurrent
multiplets are proposed. Implications for supergravity-matter systems are
discussed.Comment: 11 pages; V2: minor changes in sect. 3; V3: published version; V4:
typos in eq. (2.3) corrected; V5: comments and references adde
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